AMG 579CAS号： 1227067-61-9分子式： C25H23N5O3分子量： 441.48描述纯度储存/保存方法可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:37.8mg/mL (85.6mM)
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| 生物活性 | |
| 靶点 |
Phosphodiesterase 10A:0.1 nM
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| In vivo(体内研究) |
AMG 579 statistically reduces PCP-induced behavior in rats within 2 hours. In the PCP-LMA model, the minimum effective dose of AMG 579 was 0.3 mg/kg. AMG 579 has an excellent oral bioavailability of 72% in dogs[1].
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