EM574CAS号： 110480-13-2分子式： C39H69NO12分子量： 744.0描述来源应用纯度储存/保存方法形态密度沸点折射率PK值可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
EM574, an erythromycin derivative, is reported to be a GPR38 (motilin receptor) agonist in the human gastric antrum in vitro. This compound was found to stimulate contractions of muscle strips in a concentration dependent manner via displacement of 125I-motilin bound to smooth muscle homogenates. Experiments have shown that EM574 contains the ability to stimulate cholinergic neurons in a non-vagal pathway. Additionally, this agent has been noted to have orexigenic activity with affinity for the growth-hormone secretagogue receptor.
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| 来源 |
Semisynthetic from erythromycin A
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| 应用 |
An erythromycin derivative that is a motilin receptor antagonist
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| 纯度 |
≥95%
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| 储存/保存方法 |
Store at -20° C
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| 形态 |
Solid
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| 基本信息 | |
| 密度 |
1.19 g/cm3 (Predicted)
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| 沸点 |
804.05° C at 760 mmHg
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| 折射率 |
n20D 1.54 (Predicted)
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| PK值 |
pKa: 13.45 (Predicted), pKb: 9.21 (Predicted)
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| 可溶性/溶解性 |
Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)
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| MDL |
MFCD00886575
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| PubChem CID |
84019
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