AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.

96%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:30 mg/mL (47.4 mM)

hP-gp:32 μM (IC50), hERG:7.3 μM (IC50), CCR5:0.32 nM (IC50)

In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1].

AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3].