Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

HSPA1A抗体, HSPA1B抗体;Heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP701/HSP702; HSPA1A; HSPA1; HSX70

Rabbit

This HSPA1A/HSPA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 503-532 amino acids from human HSPA1A/HSPA1B.

Human

B

WB~~1:1000

Polyclonal Antibody

Rabbit Ig

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Cancer;Signal Transduction

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs

P08107

Mueller, T., et al., Transplantation 78(2):292-295 (2004).
Fekete, A., et al., Pediatr. Res. 54(4):452-455 (2003).
Broquet, A.H., et al., J. Biol. Chem. 278(24):21601-21606 (2003).
Bruce, C.R., et al., Diabetes 52(9):2338-2345 (2003).
Anwar, A., et al., J. Biol. Chem. 277(16):14060-14067 (2002).