RU-521CAS号： 2262452-06-0分子式： C19H12Cl2N4O3分子量： 415.23描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
RU-521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
RU.521；RU320521
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| 外观 |
Off-white to light yellow powder
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| 可溶性/溶解性 |
DMSO : 83.33 mg/mL (200.68 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
dsDNA
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| In vitro(体外研究) |
RU-521 (0.1 nM-1000 μM; 72 h) suppresses dsDNA-induced signaling in macrophage cells.
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| In vivo(体内研究) |
RU-521 (5 mg/kg ; i.p. once) reduces symptoms from sepsis in mice.
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分子结构图
