GSK5182 CAS号： 877387-37-6分子式： C27H31NO3分子量： 417.55描述纯度储存/保存方法别名靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
(E/Z)-GSK5182
|
| 生物活性 | |
| 靶点 |
ERRγ
|
| In vitro(体外研究) |
Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5.
|
| In vivo(体内研究) |
a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production.
|
分子结构图
