NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively.

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:55 mg/ml (105.44 mM)

hALDH3A1:>57 μM, ALDH1A1:7 nM, hALDH1A3:22.8 μM, hALDH2:20.1 μM, hALDH1A2:>57 μM

NCT-505 (compound 86) is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor with IC50 of 7 nM, weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM ). NCT-505 has no significant inhibitory effect on 5-hydroxyprostaglandin dehydrogenase (HPGD) and type 4 hydroxysteroid dehydrogenase (HSD17β4) (IC50, >57 μM). In addition, NCT-505 showed potent cellular viability, reducing the viability of OV-90 cells with EC50 of 2.10-3.92 μM. NCT-505 is also cytotoxic to SKOV-3-TR cells with IC50 of 1, 3, 10, 20, 30 μM in titration analysis[1].