(R)-(+)-Bay-K-8644CAS号： 98791-67-4分子式： C16H15F3N2O4分子量： 356.3描述纯度储存/保存方法别名外观光学活性IC50PK值Ki 数据可溶性/溶解性PubChem CID靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
Bay-K-8644 ((R)-(+)-)；R-4407；NI-105；(+)-BAY-K-8644
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| 外观 |
yellow powder
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| 光学活性 |
α20D +52.9º, c = 0.42 in 1,4-dioxane
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| IC50 |
Transient receptor potential cation channel subfamily A member 1: EC5050 = 20.8 µM (mouse)
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| PK值 |
pKa: 7.67 (Predicted), pKb: 1.5 (Predicted)
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| Ki 数据 |
Adenosine A1-R: Ki= 785 nM (mouse); Adenosine A3-R: Ki= 2.77 µM (human); Adenosine A3-R: Ki= 6.2 µM (rat); Adenosine A2A-R: Ki= 35.1 µM (rat)
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| 可溶性/溶解性 |
DMSO : ≥ 300 mg/mL (841.99 mM)
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| PubChem CID |
6604881
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| 生物活性 | |
| 靶点 |
IBa
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| In vitro(体外研究) |
(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor.
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分子结构图
