TeSeE purification and detection assays are available for high-throughput multispecies screening for TSE.

High Sensitivity of TeSeE^® Rapid Assays

TeSeE assays have demonstrated the highest sensitivity in independent evaluations:

• The TeSeE assay was declared the most sensitive rapid assay for bovine spongiform encephalopathy (BSE) testing in cattle by the DG SANCO in 1999
• In 2002, the second European Commission (EC) evaluation for cattle confirmed this performance by demonstrating that the TeSeE assay was still the most sensitive assay of the five new tests evaluated (EC evaluation, March 27, 2002)
• TeSeE and TeSeE sheep and goat assays (approved by DG SANCO in 2005) have demonstrated outstanding performance and are classified by the AFSSA as one of the most sensitive rapid assays for scrapie screening in ovine and caprine species
• TeSeE assay has been demonstrated to be as sensitive as immunohistochemistry (IHC) for the diagnosis of chronic wasting disease (CWD) in deer and elk by independent transmissible spongiform encephalopathy (TSE) laboratories in the U.S. and Canada

Remarkable Specificity Providing Reliable Results

Since it was introduced in 2000, the TeSeE assay has been used in many countries as a reliable tool for large-scale BSE screening programs. Based on data from large BSE-tested populations collected in these countries, the estimated specificity of the Bio-Rad TeSeE assay exceeds 99.99%.

Assay Adaptability to Any Daily TSE Testing Routine

All TeSeE rapid assays (BSE, scrapie, and CWD) can be run on the TeSeE NSP system. The TeSeE NSP system, coupled with an ELISA microplate workstation, is suitable for any throughput level. Protocol automation provides a solution that meets the needs of laboratories involved in TSE screening.

Shorter Turnaround Time and Improved Efficiency

In a continuous effort to propose cutting-edge tools to improve turnaround time and assay procedure, Bio-Rad developed a new version of the TeSeE assay, the TeSeE Short Assay Protocol (SAP). Based on the same principle, the purification remains unchanged, while the ELISA protocol is optimized and reduced by 1 hr.

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