Rabbit anti-ACE1 Polyclonal Antibody

Rabbit anti-ACE1 Polyclonal Antibody描述别名宿主特异性反应种属预测反应种属应用分子量免疫原浓度纯化方法类型储存/保存方法存储溶液背景说明组织特异性翻译后修饰细胞定位UniProt

概述
描述

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

别名
ACE1抗体;ACE 1; ACE; ACE T; ACE_HUMAN; ACE1; Angiotensin converting enzyme somatic isoform; Angiotensin converting enzyme testis specific isoform; Angiotensin I converting enzyme 1; Angiotensin I converting enzyme; Angiotensin I converting enzyme peptidyl dipeptidase A 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; Angiotensin-converting enzyme; Carboxycathepsin; CD 143; CD143; CD143 antigen; DCP 1; DCP; DCP1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; MVCD3; Peptidase P; Peptidyl dipeptidase A; soluble form; Testicular ECA
宿主
Rabbit
特异性
ACE1 Antibody detects endogenous levels of total ACE1.
反应种属
Human, Mouse, Rat
预测反应种属
Zebrafish;Rabbit;Pig;Dog;Sheep;Horse;
应用
WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
分子量
Predicted molecular weight: 150kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原
A synthesized peptide derived from Human ACE(Accession P12821), corresponding to amino acid residues S930-H958.
性能
浓度
1mg/ml
纯化方法
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
类型
Polyclonal Antibody
储存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存储溶液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
靶标
背景说明
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
组织特异性
Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
翻译后修饰
Phosphorylated by CK2 on Ser-1299; which allows membrane retention.
细胞定位
Endosome;Extracellular region or secreted;Lysosome;Plasma Membrane;
UniProt
P12821