BRL 37344, sodium salt is a potent and selective agonist of β3 adrenoceptor with Ki values of 287, 1750 and 1120 nM for β3, β1 and β2 receptors, respectively .

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

BRL 37344 Na Salt

white powder

pK_a: 3.18 (Predicted), pK_b: 8.98 (Predicted)

β3 receptor: K_i= 287 nM; β1 receptor: K_i= 1750 nM; β2 receptor: K_i= 1120 nM

Soluble in water (100 mM).

β3 receptor

BRL 37344, sodium salt is a potent and selective β3 adrenoceptor agonist. In isolated rat brown and white adipocytes, BRL 37344 significantly stimulated lipolysis with EC50 values of 5 and 56 nM in brown adipocytes and white adipocytes, respectively. In the isolated guinea pig heart, BRL 37344 (10-8-10-5 M) increased heart contractility (dP/dt) and coronary flow (CF). However, BRL 37344 (10-8 M) completely inhibited isoprenaline-induced increase in contractility, which suggested that BRL 37344 display β1-antagonistic properties.

In fasted rabbits, BRL 37344 significantly increased plasma nonesterified fatty acids (NEFA) levels through β3-adrenoceptor. However, BRL 37344 had no effect on plasma glucose levels. In mice, BRL 37344 increased circulating transaminase levels through activation of β3-adrenoceptor.