CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

>98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

NSC 69877；7-硝基吲哚-2-甲酸；7-Nitroindole-2-carboxylic acid

Orange to brown powder

DMSO : 39 mg/mL (189.2 mM)

Ethanol : 1 mg/mL (4.85 mM)

APE1

CRT0044876 potently inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and exhibits the selectivity for the inhibition of exonuclease III family. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds with an accumulation of unrepaired AP sites. CRT0044876, by inhibition of the BER pathway increases oxidative DNA damage temporally related to increased intracellular reactive oxygen species in an acidic tumor microenvironment, and thus results in cell cycle arrests and increased DNA double strand breaks, leading to cell death.