UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB₂ receptor (K_i = 1.8 nM) over the central CB₁ receptor (K_i = 150 nM).¹ UR-144 Degradant N-pentanoic acid metabolite is a potential phase I metabolite of a degradation product observed during GC-MS analysis of samples containing UR-144.^2,3,4 The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.

≥95%

Store at -20℃

1.Frost, J.M.,Dart, M.J.,Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity. Journal of Medicinal Chemistry 53, 295-315 (2010).

2.Wintermeyer, A.,Möller, I.,Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH 018. Analytical and Bioanalytical Chemistry 398, 2141-2153 (2010).

3.Chimalakonda, K.C.,Moran, C.L.,Kennedy, P.D., et al. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH 018 and JWH 073 in human urine. Analytical Chemistry 83(16), 6381-6388 (2011).

4.Lovett, D.P.,Yanes, E.G.,Herbelin, T.W., et al. Structure elucidation and identification of a common metabolite for naphthoylindole-based synthetic cannabinoids using LC-TOF and comparison to a synthetic reference standard. Forensic Science International 226(1-3), 81-87 (2013).