MLS000544460CAS号： 352336-36-8分子式： C17H12FN3O2S分子量： 341.36描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM).MLS000544460 exhibits inhibitory effects on Eya2 phosphatase-mediated cell migration and has anticancer activity.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:30 mg/mL (87.88 mM)
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| 生物活性 | |
| 靶点 |
Eya2 phosphatase:(kd)2.0 μM, Eya2 phosphatase:4 μM, Eya2 phosphatase:2.0 μM(kd), Eya2 phosphatase:4 μM
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| In vitro(体外研究) |
MLS000544460 binds to Eya2 ED (dialyzed into 10 μM EDTA to remove Mg2+) with a Kd of 0.80 μM.[1]
MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells.[1] |