NCGC 607CAS号: 1462267-07-7分子式: C24H22IN3O4分子量: 543.36描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)
产品描述 | |
描述 |
NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
可溶性/溶解性 |
DMSO:55 mg/mL (101.22 mM)
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生物活性 | |
In vitro(体外研究) |
NCGC607, a small-molecule noninhibitory chaperone of glucocerebrosidase identified by high-throughput screening and medicinal chemistry structure optimization.?This compound successfully chaperoned the mutant enzyme, restored glucocerebrosidase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treating neuronopathic Gaucher disease.?In addition, NCGC607 reduced α-synuclein levels in dopaminergic neurons from the patients with parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease.
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