Recombinant Human TMEM219 Fc Chimera Protein(Human Fc Tag)别名种属来源分子量外观形态序列标签纯度内毒素水平溶解方法储存/保存方法背景说明Accession参考文献
概述 | |
别名 |
IGFBP-3R; Transmembrane protein 219; TMEM219
|
种属 |
Human
|
来源 |
HEK293
|
分子量 |
60-65 kDa
|
外观 |
Lyophilized Powder
|
形态 |
Lyophilized from PBS, pH7.4
|
性能 | |
序列 |
SFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
标签 |
Human Fc Tag
|
纯度 |
>95% by SDS-PAGE
|
内毒素水平 |
<0.1EU/ug
|
溶解方法 |
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
|
储存/保存方法 |
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
|
靶标 | |
背景说明 |
TMEM219 is a recently discovered death receptor, which induces cell apoptosis by a Caspase-8-dependent mechanism, through the binding with its ligand, the Insulin-like growth factors binding protein 3 (IGFBP3). TMEM219 consists of four exons comprising the 915-base pair cDNA sequence on chromosome 16q13 and represents a 240-amino acid polypeptide. TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. TMEM219 is an IL-13Rα2 binding partner that plays a critical role in many Chi3l1-induced, IL-13Rα2-mediated cellular and organ responses. |
Accession |
Q86XT9-1
|
参考文献 | |
参考文献 |
1. Chang-Min Lee , Chuan Hua He.IL-13Rα2 uses TMEM219 in chitinase 3-like-1- induced signalling and effector responses.Nat Commun. 2016 Sep 15;7:12752. doi: 10.1038/ncomms12752.
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实验结果图
1μg (R: reducing conditions, N: non-reducing conditions).